GingaNinga

In animal research we often refer to genotype and phenotype. Genotype refers to the set of genes the animals the animals carry (what they are capable of expressing) and phenotype refers to the physical/clinical expression/presentation/characteristics of the animal or disease state. My guys were all “wild type” meaning they’re just “normal” standard mice and we induced the “obese phenotype” (obese disease state with the associated characteristics and physical presentation associated with the disease) with the two high fat diets. 60% had a greater impact on inducing these changes compared to the control group than the 40% group.

Why stop at justices, how about the president?

Oh I agree, I think he’s an absolute tool and he’s doing it for ego and legacy (we can clearly see this play out with all the tariff nonsense) but I bet he has smarter people advising on that plan. It drives me nuts that someone can so consistently fail upward their entire life its unbelievable.

interesting! ya this is a whole world I know very little about but it seems very relevant these days.

I think its trade and military strategy. Ice caps are melting, arctic will become a major global shipping lane, he wants military bases and ports through which major commerce will flow. Its just something else for the US to control and extort.

Ya I’m not an engineer at all so I’m not sure how hard it is to store that much power but that always seemed like a good idea. Even for electric cars, if we designed a universal battery pack good for a few hundred kilometres that we could swap out at recharge stations I feel like that would be a smart way to do things. But again I have no idea if thats feasible or how it would be implemented.

no worries, I love talking about work! Nutrition is especially interesting given how relevant it is in our day to day lives and how complicated everything is between food itself, genetics and our gut microbiome. I could read about it all day, and not because I had to for two years!

60% produced a more dramatic phenotype and I remember it being the most popular diet in animal studies (I did all this 10 years ago so the details are a little fuzzy) so I’d probably go with that one.

Compliance wasn’t an issue since we we ran the study in mice and they all liked the food. they’re all basically clones so so it helps eliminate a LOT of variables. As expected we found the 60% diet induced a much more dramatic phenotype than the 40% but both induced obesity in general, but even ONLY having 60 vs 40% fat the differences were significant enough to make me reluctant to compare the two HFDs especially when you dive into microbiota stuff. I wouldn’t say its apples and oranges, more like apples and crab apples… or something.

We used purified high fat diets, one at 40% and one at 60% and compared the two. We had a whole other project where each group were supplemented with lentils but we I focussed on just the difference between those two diets where the only variable between them were the carb/fat percentage, they were otherwise the same/pure.

I did my masters thesis on high fat diets and while I was doing my lit review I realized there was no standard for what a “high fat diet” even is. There are SO many variables and its insane some of the logic leaps some studies come to to complete a narrative.

Thats pretty wild. so much hate and fear, its exhausting.

slam

slam

Ah the middle of the room where everyone can see and hear us, excellent spot for a private meeting.

AI is completely unreliable to the point of almost being dangerous in sciences. The more niche you get with the question the more likely it is to give you a completely incorrect answer. I’d rather it admit that it doesn’t know.

calls on PRTS

Is that the same company that makes histology stuff? half my lab is Leica equipment

Well Powell has the “dual mandate” of price stability and low unemployment, so by definition its his job to maintain a stable environment. So that must be pretty interesting right now lol.

It drives me nuts so I’ve been commenting slam on every post I happen to come across, its like 4-5 per day. I’m trying to spread awareness of slam fatigue. On the bright side I saw the word “blasts” used today which I don’t actually mind! its a bit more interesting. Theres just something about the word slam and how often its used that grinds my gears I can’t explain it! I wish they’d be more creative like “throws a haymaker!” or “RKO’d” or “falcon punches”.